Letterer-Siwe disease

Acute, fulminant disease affecting infants and children less than 2 years of age
Typically less skeletal involvement
Systemic disease associated with hepatosplenomegaly, adenopathy, central nervous system involvement, fever, anemia, thrombocytopenia
Potentially fatal clinical course
Treatment includes corticosteroids and chemotherapy

Last Updated on June 27, 2024

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