Clear cell chondrosarcoma

Rare, low-grade, malignant tumor
Most common in 20- to 40-year-olds
Generally found in epiphysis or metaphysis of long bone, particularly proximal femur and humerus
Radiographic presentation:
- Geographic osteolytic lesion at end of long bone
- Cortex generally intact, but may be expanded
- Often has sharp sclerotic margins; exception: larger lesions, which may have indistinct margins
- Calcification within lesion uncommon
Microscopic presentation:
- Admixture of clear cells, chondroid matrix, and giant cells
- Ossification may be present
Tumor may resemble a benign tumor radiologically (such as chondroblastoma); however, can metastasize and must be treated with wide resection

Last Updated on June 27, 2024

OrthopaedicsOne Living Semantic Network

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