|
Year |
2002 |
|---|---|
|
Question Number |
79. |
|
Category |
Orthopaedic Science |
Question
The common pathologic process that occurs in patients with rickets, regardless of the cause, is a failure to:
a. Mineralize the matrix in the zone of provisional calcification
b. Adequately synthesize chondroitin sulfate
c. Adequately synthesize type II collagen
d. Metabolize and degrade glycoproteins
e. Resorb the primary spongiosum
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Answer (click for answer)
The correct answer is (a).
This is fairly straight-forward. The underlying pathology of rickets, whether it is nutritional (Vitamin D, Calcium, or phosphate deficiency), Hereditary Vitamin D deficiency, or Familial Hypophosphatemic rickets is a failure of mineralization of bone matrix, specifically at the zone of provisional calcification.
Reference: Miller, Mark. Review of Orthopaedics: 3rd edition. WB Saunders Publishing: Philadelphia. © 2000. pp. 424-427.